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PERCOCET DOSAGE AND ADMINISTRATION
Firstly, use the lowest effective dose for the shortest duration. Individualize. Initially 1–2 tablets of 2.5mg/325mg every 6 hours as needed. 5mg/325mg, 7.5mg/325mg, 10mg/325mg: 1 tablet every 6 hours as needed. Maximum 4g acetaminophen/day. Hepatic impairment: start with lower doses and titrate cautiously; monitor. With concomitant use or discontinuation of CYP3A4 inhibitors or inducers: consider close monitoring and dose adjustment (see full directions for use).Buy Percocet in Australia
CONTRAINDICATIONS TO PERCOCET
Secondly, significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative agents. Known or suspected GI obstruction, including paralytic ileus
Nevertheless, life-threatening respiratory depression; monitor within first 24–72 hours after initiation of therapy and after dose escalation. Accidental exposure may result in fatal overdose (especially in children). COPD, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression; monitor and consider non-opioid analgesics. Abuse potential (monitor). Adrenal insufficiency. Head injury. Increased intracranial pressure, brain tumors; monitor. Seizure disorder.
CNS depression. Impaired consciousness, coma, shock; avoid. Increased risk of hepatotoxicity with acetaminophen doses > 4g/day, alcohol dependent. Underlying liver disease. Biliary tract disease. Acute pancreatitis. Discontinue at first sign of rash or other hypersensitivity.
Moreover, Increased risk of hypotension, respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); concomitant use only in patients for whom alternative options are inadequate; limit dosage/duration to minimum necessary; monitor. During or within 14 days of MAOIs: not recommended.
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Avoid concomitant use of other acetaminophen-containing products. Risk of serotonin syndrome with serotonergic medications (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Avoid concomitant use of opioids with mixed agonists/antagonists (e.g., butorphanol, nalbuphine, pentazocine) or partial agonists (e.g., buprenorphine); this may reduce effect and/or cause withdrawal symptoms. Enhanced by CYP3A4 inhibitors (e.g., macrolides, azole antifungals, protease inhibitors). Antagonized by CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin).
Furthermore ,may be antagonized by oral contraceptives, activated charcoal. May be potentiated by β-blockers, probenecid. May antagonize diuretics, lamotrigine, zidovudine; monitor. Paralytic ileus may occur with anticholinergics. May interfere with cocaine or marijuana testing and blood glucose levels.
Lastly, Drowsiness, dizziness, sedation, nausea, vomiting, euphoria, dysphoria, constipation, pruritus; respiratory depression, severe hypotension, syncope; rarely: severe skin or hypersensitivity reactions